Mechanistic Insight into the Tin-catalyzed Conversion of Tetrose Sugars to Alpha-Hydroxy Acid Platform Molecules with <em>in situ</em> NMR

Dusselier, Michiel

Wednesday, June 5, 2013

Ballroom C (Galt House Hotel)

Michiel Dusselier¹, Filip de Clippel¹, Pieter van Wouwe¹, David Gammon² and Bert F. Sels¹, (1)Katholieke Universiteit Leuven, Belgium, (2)University of Cape Town, South Africa.

Homogeneous tin salts are excellent catalysts for the conversion of tetroses to new four-carbon alpha-hydroxy acid platform molecules. Even at room temperature remarkable activities were displayed. An elaborated reaction pathway is proposed and corroborated with an in situ NMR study, labeling and control experiments.

Extended Abstracts:

Abstract NAM23_M Dusselier.pdf (48.9KB) - Extended Abstract

P-W-BRC-100 Mechanistic Insight into the Tin-catalyzed Conversion of Tetrose Sugars to Alpha-Hydroxy Acid Platform Molecules with in situ NMR