P-We-77 A Unique High-Sensitivity Bioassay Incorporating a Heterogeneously Catalyzed Redox Amplification Reaction

Wednesday, June 8, 2011
Ontario Exhibit Hall (Detroit Marriott Hotel at the Renaissance Center )
Henry J. Gysling and Mark Lelental, CatAssays, Rochester, NY
A high-sensitivity bioassay uses a detection protein for a disease biomarker that is labeled with Pd(2+).  Treatment of this  metalloprotein with a redox solution containing a leuco dye and reducing agent initially reduces the Pd(2+) to Pd(0) which then catalyzes reduction of the leuco dye to the assay dye signal. 

Extended Abstracts: